A staff scientist (molecular geneticist) is available in the Grønbæk Group at BRIC, University of Copenhagen

We are searching for a skilled molecular geneticist with flair for bioinformatics with specific interest in investigating the underlying mechanisms of clonal hematopoiesis and mosaic chromosomal aberrations in a large population-based cohort.

Our research/The group
The focus of the Grønbæk group is Translational Hematology. The group is affiliated with both Biotech Research and Innovation centre (BRIC), University of Copenhagen and Rigshospitalet (Central Copenhagen University Hospital).

The current position is part of the current project: AGE-RELATED DISEASES: CAUSES, MECHANISMS AND CONSEQUENCES OF MUTATED BLOOD CELLS WITH MULTIPLE ABERRATIONS

The overall aim of the project is to identify ”high risk” clonal hematopoiesis (CH), to identify the drivers of CH and understand the mechanisms of clonal growth and to identify non-toxic drugs that may control this growth. This will form the basis for prospective clinical trials on disease prevention.

We have access to a large cohort 500.000 Danes characterized by existing SNP arrays. This is being analysed for mosaic chromosomal aberrations. In a subset of these, we will implement a high through-put analyses of the 8 most common CHIP mutations to establish a cohort with high-risk CH for interventional trials. All data will be aligned with germline genetics and Danish health registry data.

Our location at the Copenhagen Biocentre/BRIC provides optimal conditions for interaction with the basic scientists at the Finsen laboratory and BRIC. The group currently consists of 11 scientists, MD/scientists and students, one research coordinator, 2 research nurses and 2 laboratory technicians.

Your job
We are searching for a skilled molecular geneticist who is very interactive and enjoys collaborations with other scientists – including younger scientists and clinician scientists.

Your tasks will include:

• Laboratory work: Develop the high trough put next generation sequencing analyses together with a skilled technician.
• Analyze mCA in SNP arrays (this is currently in process in our lab).
• Analyze large sequencing data using R language.
• Compare to epidemiological data.
• Perform Mendelian randomization studies.
• Collaborate with colleagues in hematology, cardiology, basic biology and beyond.
• Participate in grant and manuscript writing.
• Present at local and international meetings.
• Introduction of lab techniques to new lab members and students.
• Collaborate with both scientists and clinicians.

Start: September 1st 2024 or after agreement

Duration: 2 years

Qualifications
We expect you to be a highly motivated and highly ambitious, independent scientist with the following qualifications:

• Preferentially with a PhD in Life Sciences.
• A strong background in genetics of normal and malignant hematopoiesis and molecular hematology techniques.
• Comprehensive lab and analytic skills in genetics.
• Good knowledge of genetic epidemiology.
• A basic understanding of bioinformatics.
• Publication and presentation record in peer reviewed journals and international conferences.
• Excellent written and spoken English skills.
• Very collaborative.
• Good social skills.

For further information regarding the position, please contact Professor Kirsten Grønbæk, [xxxxx] phone + [xxxxx] / +[xxxxx]

Place of employment
The workplace is at the Bartholin Institute which is part of Rigshospitalet, University of Copenhagen. The Bartholin Institute is located at Copenhagen Biocentre/BRIC, close to the centre of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and a number of core facilities (animal unit, flow cytometry, in vivo imaging, NGS, etc.) shared between the 23 research groups at BRIC ([xxxxx] and the neighbouring Finsen Laboratory. We have weekly journal clubs, data clubs, seminars with invited speakers and a young researchers club ASAP and our own PhD programme, MoMeD.

Terms of salary and employment
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Taxation and The Academics Central organization.

Application
The application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page).
2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
3. A certified/signed copy of a) PhD certificate and/or b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
4. List of publications.

Recommendation
Furthermore, the applicant should provide two letters of recommendation or two references. To be taken into consideration, the letters must be signed by the supporting person on paper with institutional letter head and in PDF-format.

Application deadline June 16th 2024

We reserve the right not to consider material received after the deadline, and not to consider applications or letters of recommendation that do not live up to the above-mentioned requirements.

Interviews will preferentially be June 19th

Kilde: [xxxxx]