Scientist - High Throughput Sequencing for Biomarker Discovery (1-year Full-time Position)

Are you passionate about harnessing the power of Next-Generation Sequencing (NGS) to unlock the secrets of the genome and discover biomarkers to understand drug and disease mechanisms? Look no further! Translational Research at Novo Nordisk is seeking a dynamic and talented Scientist to join our Biomarker Discovery and Qualification (BDQ) team. If you have a strong background in cardiometabolic disease biology combined with high throughput sequencing expertise, then apply today! The position As a Scientist in Translational Research, you will get the opportunity to discover and utilize novel biomarkers to de-risk early clinical programs. Some of your main tasks will include:

Designing and establishing NGS-based assays to profile transcriptomic, genomic and epigenomic alterations in cellular models relevant for cardiometabolic diseases

Implementing and executing high throughput sequencing methods such as DRUG-seq, PLATE-seq or census-seq

Analyzing NGS data to identify candidate biomarkers associated with treatment response and disease modulation

Collaborating closely with bioinformatics and computational biology teams to integrate multi-omics data and advanced data analysis

Validating candidate biomarkers using orthogonal techniques including qPCR, ddPCR and Olink

Staying abreast of the latest advancements in NGS technologies and contribute to the development of novel experimental approaches

Qualifications You hold a Master’s degree in Genomics, Genetics, or related field with a strong focus on cardiometabolic disease biology and NGS technologies combined with 3 years of relevant experience in pharma, biotech, or academia. Alternatively, you come with a PhD in Life Sciences with substantial NGS experience within metabolic diseases. To thrive and succeed in the role, you must have:

A background in metabolic disease biology and hands-on-experience in culturing primary human cells relevant to cardiometabolic diseases

Hands-on experience in operating Illumina sequencing platforms and sequencing methods such as DRUG-seq, PLATE-seq and census-seq methods

NGS library preparation, automation and data analysis tools (e.g., R, Python, bioconductor)

Demonstrated expertise in single cell transcriptomics using platforms such as 10X chromium and molecular biology methods such as qPCR

Additionally, it would be advantageous that you also have:

Proven expertise in implementing and using , spatial transcriptomics, DNA methylation and the Olink platform

Strong background in molecular biology techniques, including nucleic acid extraction, PCR, gene expression analysis and ddPCR

NGS experience applied to genomic and epigenomic research

Excellent analytical and problem-solving skills, with the ability to interpret complex NGS data to identify candidate biomarkers

As a person, you exhibit a strong translational mindset, excellent communication and interpersonal skills, with the ability to effectively collaborate with multidisciplinary teams. Being proactive and a dedicated team player is crucial for team-based work and knowledge sharing. About The Department At the Biomarker Discovery & Qualification department, we discover and qualify TE, PoM and disease modulation biomarkers. We employ human in vitro / ex vivo systems and in vivo animal models as well as apply omics technologies to generate high-quality biomarker data to guide decision-making in research and early development. Currently, the department consists of 9 scientists and is part of the Translational Research VP area. Other departments in Translational Research include Biomarker Assay Development, Omics Technologies and Translational Imaging. Translational Research is part of Global Translation, an organisational area responsible for the application of translational approaches across all the therapy areas in Novo Nordisk. Our ambitious goal is to ensure early, data-driven decision-making in clinical trials by application of target engagement, proof-of-mechanism, and disease modulation biomarkers as well as enabling precision medicine. Global Translation is part of [xxxxx]´s Research & Early Development and is located in Måløv, Greater Copenhagen. Working at [xxxxx] At [xxxxx], we do not wait for change. We drive it. We are a dynamic company in an even more dynamic industry, and we know that what got us to where we are today is not necessarily what will make us successful in the future. We embrace the spirit of experimentation, striving for excellence, without fixating on perfection. We never shy away from opportunities to develop we seize them. From research and development to manufacturing, marketing, and sales – we’re all working to move the needle on patient care. Contact For further information, please contact Madhan Selvaraj, Director Biomarker Discovery & Qualification at [xxxxx] Deadline 10 June 2024. Applications will be reviewed on an ongoing basis, so we encourage you to apply as soon as possible. You do not need to attach a cover letter to your application, but please include a few sentences about why you are applying in your resume or CV. To ensure an efficient and fair recruitment process, please refrain from adding a photo to your CV. We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At [xxxxx] we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.