Principal Scientist for in vitro biological screening assays

Do you have a strong passion for developing in vitro biological assays for the functional screening of drug candidates? Are you eager to become part of an international, ambitious, and collaborative team at the Centre for Functional Assays & Screening (CFAS)? If so, we encourage you to apply for the role of Principal Scientist in our center. The Position
We're on the hunt for a talented individual who can develop predictive in vitro screening tools to facilitate medium- and high-throughput screening of small molecules and protein-based drug modalities. In this exciting role, you will be responsible for:

Designing, developing, and conducting advanced and robust cellular in vitro assays to drive the selection of drug candidates.

Contributing to the development and improvement of screening strategies for the selection of the best drug candidates across different therapeutic areas.

Managing the outsourcing of screening assays to CROs for high-throughput screening of small molecules.

Utilizing your subject matter expertise in small molecules to facilitate knowledge sharing and coordinate activities in the area.

Providing informal scientific leadership and mentorship to colleagues.

You will collaborate closely with project teams with members across the research organization, department scientists, and laboratory technicians, and represent the department across a variety of projects. The work environment is dynamic and innovative, providing opportunities to interact with colleagues from our global research sites in Denmark, the US, the UK, and China, thereby presenting an excellent opportunity to establish a strong global scientific network. Qualifications
To thrive and succeed in this role you have:

A PhD in cell biology, immunology, biochemistry, or a related discipline and at least 7 years of post-degree experience from the pharmaceutical industry with preclinical development of drug candidates.

Substantial experience with small molecule drug discovery and development.

Proficiency in the design, development, and execution of cellular in vitro functional assays utilizing both engineered cell lines and primary cells. Assays of relevance comprise but are not limited to molecular pharmacology assays detecting signal transduction e.g. reporter gene assays, receptor binding assays, high-content imaging, and FRET assays.

Experience with liquid handlers (e.g. Biomek, Hamilton, Tecan or Echo) for assay miniaturization and automated/semi-automated workflows for efficient screening processes.

As an individual, you are naturally curious and proactive, possessing excellent communication skills. You excel in establishing and maintaining external and internal connections. You thrive in a dynamic and evolving work environment, and you enjoy collaborating within teams to share knowledge and learn from others. Your passion for science and your ability to drive and advance projects inspire those around you. About the Department
The Centre for Functional Assays & Screening is part of Global Research Technologies at [xxxxx] located in Maaloev in the Copenhagen area of Denmark. We specialise in the design and execution of a variety of medium- and high-throughput screening assays with relevant biological read-outs and with a strong focus on automation and digitalisation. We deliver high-quality in vitro data to support the identification of drug candidates with desired functionalities in close collaboration with other parts of the research organization. CFAS consists of three sub-departments and comprises a total of 16 scientists, four associate scientists, 14 technicians as well as one lab trainee and two students. You will be part of a high-performing, multidisciplinary team exploring and identifying new treatment options for diabetes, obesity, MASH, cardiovascular and kidney disease, haemophilia, and other rare blood and endocrine disorders. Working at [xxxxx]
At [xxxxx], we don’t wait for change. We drive it. We’re a dynamic company in an even more dynamic industry, and we know that what got us to where we are today is not necessarily what will make us successful in the future. We embrace the spirit of experimentation, striving for excellence without fixating on perfection. We never shy away from opportunities to develop, we seize them. From research and development, through to manufacturing, marketing and sales – we’re all working to move the needle on patient care. Contact
For further information, please contact Madeleine Dahlbäck, Director Functional Assays & Screening, by email [xxxxx] Deadline
12 Jun 2024. Applications will be evaluated on an ongoing basis. We are looking to fill this position as soon as possible. You do not need to attach a cover letter to your application, but please include a few sentences about why you are applying in your resume or CV. To ensure an efficient and fair recruitment process, please refrain from adding a photo in your CV.
We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At [xxxxx] we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.